Biocompatibility of nanomaterials

• Surface modification of gold nanorods and its effect on inflammatory response in macrophage cells

We investigated the effects of different surface modifications and concentrations of GNRs on inflammatory cytokine induction in murine macrophage Raw264.7 cells. The release of two inflammatory cytokines (interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α)) were investigated in this study because they are strongly associated in sepsis syndrome and other immune diseases.
For more details, please go to http://onlinelibrary.wiley.com/doi/10.1002/ppsc.201200115/abstract

• Cytotoxicity of RAFT Polymers

The reversible addition-fragmentation chain transfer (RAFT technique) has been increasingly used to generate polymers for potential biological applications. However, the toxicity of the RAFT-polymers has received limited attention. In this study, the in vitro cytotoxicity of three different, RAFT-synthesized, water-soluble polymers was investigated using three different adherent cell lines via CellTiter-Blue cell viability and the cytosolic enzyme lactate dehydrogenase (LDH) cytotoxicity assays.
For more details, please go to http://pubs.acs.org/doi/abs/10.1021/bm901129x